Signal Transduction: Pathways, Mechanisms and Diseases Teachingagraduatecourseonsignaltransductioninthefallof2007wasvery enjoyable. Eachweek,mystudentsandIdiscussedarecentlypublishedresearch paperinsomeareaofsignaling,arguedabouttheappropriatenessofthemethod- ogyusedintheresearch,thedesignoftheexperiments,andwhethertheconc- sions drawn were supported bythe results presented. Finally, each student was askedtolistwhatwasgoodandwhatwasde?cientinthepaperandwhethershe/he wouldhaveacceptedorrejectedithadshe/herevieweditforpublication. Fora goodnumberofrecentpapers,aconsistentcomplaintofthestudentswasthatthe backgroundtotheresearchwasnotadequatelydescribed. Itcanofcoursebeargued that students should research the background. Either way, the need for a good sourceofbackgroundmaterialinordertoappreciatetheresearchpresentedina paperbecameapparenttomeandwastheinspirationfordevelopingthisbook. Thegoalinbringingthisbookwastoprovidestudentswithareviewofrecent developmentsinspeci?careasofcurrentinterestinsignaltransduction,suf?ciently indepthtomakerecentresearchpublicationsaccessible. However,giventhewide rangeofresearchtopicsbeinginvestigatedtodayinsignaling,achoicehadtobe madetofocusonaselectfew. Thischoicewasmadenotonlykeepingthecurrent research interest in mind, but also with the anticipation that these areas will continuetobeofinterestoverthenextseveralyears. Inchoosingpapersfordiscussioninmyclass,Ilookforhealth-relatednessofthe research,andthatisre?ectedinthelistofthebroadareascoveredinthisbook-G proteincoupledreceptors,growthfactors,nuclearreceptors,reactiveoxygenand nitrogenspecies,cellcycleandcancer;theemphasishasbeenonareasofsignaling researchwithimmediateclinicalsigni?cance. Ibelievethisbookwillservewellas supplementalreadingmaterialforundergraduateandgraduatestudentswithsimilar interest. Anotherareacoveredinthisbook,onenotoftenhighlightedinsignaltransd- tionbooks,isthatofsignalingplatforms,whichisemergingasasigni?cantareaof researchrelevanttocellularmetabolism,cellproliferation,differentiation,apop- sis, [...] Autor: Ari Sitaramayya Wydawnictwo: Springer Rok wydania: 2009 Okładka: twarda Liczba stron: 437 Wymiary: 15.5 x 24.5 x 3 cm Ilustracje: XI, 437 p. Język: angielski ISBN: 9783642021114