Optimization in Drug Discovery: In Vitro Methods

Optimization in Drug Discovery: In Vitro Methods Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve 'drug-like' characteristics in addition to efficacy properties and good safety profiles of drug candidates. Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development. Autor: Gary W. Caldwell, Zhengyin Yan Wydawnictwo: Humana Press Inc. Rok wydania: 2013 Okładka: twarda Liczba stron: 597 Wymiary: 17.8 x 25.4 x 3.8 cm Ilustracje: 104 Tables, black and white; 49 Illustrations, color; 64 Illustrations, black and white; XVII, 597 p. 113 illus., 49 illus. in color. Język: angielski ISBN: 9781627037419