Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects

Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects Unique in its two-fold protective function, alpha-lipoic acid has drawn unprecedented interest for its role as a coenzyme in mitochondrial energy metabolism and as an antioxidant and cell redox modulator. This book covers discoveries in the chemistry, biological action, and significance of alpha-lipoic acid in energy production and health. Section I reviews the molecular structure, biosynthesis, and characterization of lipoic acid. Section II describes metabolic aspects, human pharmacodynamics, energy production, and antioxidant activity. Section III discusses clinical aspects, treatment of metabolic syndromes, and loss of mitochondrial function with lipoic acid supplementation. The recognition of oxidative stress as a major factor in health, aging, and disease has led to a surge in research aimed at uncovering effective countermeasures in the form of antioxidants. Unique in its two-fold protective function, alpha-lipoic acid has drawn unprecedented interest as a coenzyme in mitochondrial energy metabolism and as an antioxidant and cell redox modulator. Mounting data regarding its potential health benefits demands an authoritative, single-source reference to codify current knowledge and guide future research. A state-of-the-science compilation, Lipoic Acid follows the history of this potent coenzyme and the latest discoveries regarding the chemistry, biological action, and significance in energy production, antioxidant activity, and health. The book is divided into three sections: ·         Section I: Discovery and Molecular Structure reviews the early studies leading to the discovery of alpha-lipoic acid and explains the molecular structure, biosynthesis, and the characterization of lipoic acid and its chemical derivatives. ·         Section II: Metabolic Aspects describes in detail the human pharmacokinetics of alpha-li Wydawnictwo: Taylor & Francis Rok wydania: 2019 Okładka: miękka Liczba stron: 556 Wymiary: 22.9 x 15.2 cm Język: angielski ISBN: 9780367387655