Genome Instability: Methods and Protocols

Genome Instability: Methods and Protocols This volume presents forty-two methods and protocols to analyze diverse aspects of genome instability. Chapters detail mutagenesis and repair, methods to quantify and analyze the properties of DNA double-strand breaks, profile replication, replication proteins strand-specifically, genome instability, fluorescence microscopic techniques, and genomic and proteomic approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genome Instability: Methods and Protocols aims to provide a comprehensive resource for the discovery and analysis of the proteins and pathways that are critical for stable maintenance of the genome. Autor: Marco Muzi Falconi, Grant W Brown Wydawnictwo: Humana Press Inc. Rok wydania: 2017 Okładka: twarda Liczba stron: 663 Wymiary: 17.8 x 25.4 x 3.7 cm Ilustracje: 106 Tables, color; 100 Illustrations, color; 33 Illustrations, black and white; XVI, 663 p. 133 illus., 100 illus. in color. With online files/update. Język: angielski ISBN: 9781493973057